Format

Send to

Choose Destination
Toxins (Basel). 2010 Nov;2(11):2622-44. doi: 10.3390/toxins2112622. Epub 2010 Oct 29.

Tetanus toxin C-fragment: the courier and the cure?

Author information

1
LAGENBIO-I3A, Veterinary School, Aragón Institute of Health Sciences (IACS), Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain. jtoivonen.iacs@aragon.es

Abstract

In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic C-fragment of tetanus toxin (TTC), provided either as protein or encoded by non-viral naked DNA plasmid, binds pre-synaptic motor neuron terminals and can facilitate the retrograde axonal transport of desired therapeutic molecules to the CNS. Alleviated symptoms in animal models of neurological diseases upon delivery of therapeutic molecules offer a hopeful prospect for TTC therapy. This review focuses on what has been learned on TTC-mediated neuronal targeting, and discusses the recent discovery that, instead of being merely a carrier molecule, TTC itself may well harbor neuroprotective properties.

KEYWORDS:

gene therapy; motor neuron disease; neurodegenerative disease; retrograde transport; tetanus toxin C-fragment; therapeutic molecules

PMID:
22069568
PMCID:
PMC3153173
DOI:
10.3390/toxins2112622
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center