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Int J Mol Sci. 2015 Dec 18;16(12):30309-20. doi: 10.3390/ijms161226234.

Human Anti-Oxidation Protein A1M--A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy.

Author information

1
Section for Infection Medicine, Department of Clinical Sciences in Lund, Lund University, Lund 221 84, Sweden. jonas.ahlstedt@med.lu.se.
2
Lund University Bioimaging Center, Lund University, Lund 221 84, Sweden. thuy.tran@med.lu.se.
3
Section of Medical Radiation Physics, Department of Clinical Sciences in Lund, Lund University, Lund 221 84, Sweden. sven-erik.strand@med.lu.se.
4
Section for Infection Medicine, Department of Clinical Sciences in Lund, Lund University, Lund 221 84, Sweden. magnus.gram@med.lu.se.
5
Section for Infection Medicine, Department of Clinical Sciences in Lund, Lund University, Lund 221 84, Sweden. bo.akerstrom@med.lu.se.

Abstract

Peptide receptor radionuclide therapy (PRRT) has been in clinical use for 15 years to treat metastatic neuroendocrine tumors. PRRT is limited by reabsorption and retention of the administered radiolabeled somatostatin analogues in the proximal tubule. Consequently, it is essential to develop and employ methods to protect the kidneys during PRRT. Today, infusion of positively charged amino acids is the standard method of kidney protection. Other methods, such as administration of amifostine, are still under evaluation and show promising results. α₁-microglobulin (A1M) is a reductase and radical scavenging protein ubiquitously present in plasma and extravascular tissue. Human A1M has antioxidation properties and has been shown to prevent radiation-induced in vitro cell damage and protect non-irradiated surrounding cells. It has recently been shown in mice that exogenously infused A1M and the somatostatin analogue octreotide are co-localized in proximal tubules of the kidney after intravenous infusion. In this review we describe the current situation of kidney protection during PRRT, discuss the necessity and implications of more precise dosimetry and present A1M as a new, potential candidate for renal protection during PRRT and related targeted radionuclide therapies.

KEYWORDS:

A1M; PRRT; antioxidation; glomerulus; kidney; octreotide; oxidative stress; radioprotection; tubule

PMID:
26694383
PMCID:
PMC4691176
DOI:
10.3390/ijms161226234
[Indexed for MEDLINE]
Free PMC Article

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