Format

Send to

Choose Destination
Front Psychiatry. 2018 Apr 24;9:133. doi: 10.3389/fpsyt.2018.00133. eCollection 2018.

Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study.

Tzeng NS1,2, Chang HA1,2, Chung CH3,4,5, Kao YC1,6, Chang CC1, Yeh HW1,7,8,9, Chiang WS1, Chou YC5, Chang SY10,11, Chien WC3,4,12.

Author information

1
Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
2
Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
3
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
4
Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan.
5
School of Public Health, National Defense Medical Center, Taipei, Taiwan.
6
Department of Psychiatry, Tri-Service General Hospital, Song-Shan Branch, National Defense Medical Center, Taipei, Taiwan.
7
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan.
8
Department of Nursing, Tri-Service General Hospital, School of Nursing, National Defense Medical Center, Taipei, Taiwan.
9
Department of Nursing, Kang-Ning University (Taipei Campus), Taipei, Taiwan.
10
Division of Chest and Critical Medicine, Department of Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
11
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
12
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Abstract

Background/objective:

Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan.

Methods:

This cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000-2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray's competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up.

Results:

Of the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (p < 0.001). Fine and Gray's competing risk model analysis revealed that the adjusted HR was 1.659 (95% CI = 1.602-1.717, p < 0.001). In this study, we found that the groups of atopic dermatitis alone and the allergic rhinitis + atopic dermatitis were associated with a lower risk of psychiatric disorders, but all the other four groups, such as bronchial asthma alone, allergic rhinitis alone, bronchial asthma + allergic rhinitis, bronchial asthma + atopic dermatitis, and the combination of all these three allergic diseases, were associated with a higher risk of psychiatric disorders.

Conclusion:

Allergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan.

KEYWORDS:

National Health Insurance Research Database; Taiwan National Health Insurance Program; allergic rhinitis; atopic dermatitis; bronchial asthma; cohort study; psychiatric disorders; risk factors

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center