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Artif Cells Blood Substit Immobil Biotechnol. 2010 Oct;38(5):223-9. doi: 10.3109/10731199.2010.488635.

Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.

Author information

1
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University/JHMI, 600 North Wolfe Street, Baltimore, MD 21287, USA.

Abstract

The effect of transfusion of PEGylated hemoglobin (PEG-Hb) was evaluated in anesthetized rats subjected to 2 hours of focal cerebral ischemia and 1 day of reperfusion. PEG-Hb was stored in the carboxy state (PEG-COHb) to reduce autooxidation and increase the shelf life. Transfusion of 10 ml/kg of PEG-COHb at 20 minutes of ischemia did not alter arterial blood pressure or increase red cell flux in the ischemic core. Plasma hemoglobin increased to only 0.6 g/dL, yet infarct volume was markedly decreased and neurological deficits were improved. We conclude that early topload transfusion of PEG-COHb protects the brain from ischemic stroke.

PMID:
20486873
PMCID:
PMC3121099
DOI:
10.3109/10731199.2010.488635
[Indexed for MEDLINE]
Free PMC Article

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