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Anticancer Res. 2018 May;38(5):2755-2760.

Moesin Involvement in Oral Carcinogenesis of the Lower Lip.

Author information

1
Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
2
Fundação Pio XII Institution, Cancer Hospital of Barretos, Barretos, São Paulo, Brazil.
3
Rede D'Or Hospitals Network, Pathology Division, São Paulo, Brazil.
4
Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Hospital, São Paulo, Brazil.
5
Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil denisetostes@usp.br.

Abstract

BACKGROUND/AIM:

This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis.

MATERIALS AND METHODS:

Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test.

RESULTS:

The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates.

CONCLUSION:

Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma.

KEYWORDS:

Oral cancer; biomarkers; moesin; squamous cell carcinoma

PMID:
29715096
DOI:
10.21873/anticanres.12518
[Indexed for MEDLINE]

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