Format

Send to

Choose Destination
Oncotarget. 2018 Apr 24;9(31):21630-21640. doi: 10.18632/oncotarget.24850. eCollection 2018 Apr 24.

Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer.

Author information

1
School of Pharmacy, Federal University of Goiás (UFG - Universidade Federal de Goiás), Goiás, Brazil.
2
Innovation in Cancer Laboratory, Center of Translational Research in Oncology, Cancer Institute of São Paulo (ICESP - Instituto do Câncer do Estado de São Paulo), Faculty of Medicine of University of São Paulo (FMUSP - Faculdade de Medicina da Universidade de São Paulo), São Paulo, São Paulo, Brazil.
3
Laboratory of Oncovirology, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP - Universidade de São Paulo), São Paulo, São Paulo, Brazil.
4
Department of Obstetrics and Gynecololy, State University of Campinas (UNICAMP - Universidade Estadual de Campinas), Campinas, São Paulo, Brazil.
5
Laboratory of Medical Research, Faculty of Medicine of University of São Paulo (Faculdade de Medicina da Universidade de São Paulo-FMUSP), São Paulo, São Paulo, Brazil.
6
Institute of Life Sciences and Health, Faculty of Health Sciences, (ICVS), University of Minho, Braga, Portugal.
7
International Research Center, A.C. Camargo Cancer Center, São Paulo, São Paulo, Brazil.
8
Department of Pathology, State University of Campinas (UNICAMP - Universidade Estadual de Campinas), Campinas, São Paulo, Brazil.
9
Department of Radiology and Oncology, Faculty of Medicine of University of São Paulo (FMUSP - Faculdade de Medicina da Universidade de São Paulo-USP), São Paulo, São Paulo, Brazil.

Abstract

It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%). There was no association between SOD2 expression and HPV 16 and/or 18 detection for every lesion analyzed. Binary Logist Regression revealed that strong SOD2 expression (OR: 27.50, 6.16-122.81) and HPV 16 and/or HPV 18 (OR: 12.67, 4.04-39.74) were independently more associated with CIN3 than non-neoplastic cervix. Strong SOD2 expression (OR: 3.30, 1.23-8.86) and HPV 16 and/or HPV 18 (OR: 3.51, 1.03-11.87) were independently more associated with ADC than SCC. Similar findings for SOD2 expression were observed by the Cochran Mantel-Haenszel test, controlling for HPV-16 and/or HPV 18. In conclusion, the expression of SOD2 was increased in CIN3 and SCC, and more increased in cervical ADC than in SCC. Strong SOD2 expression was statistically independent of the presence of HPV 16 and/or 18. These findings suggest that the mitochondrial antioxidant system and HPV infection could follow independent pathways in the carcinogenesis of cervical epithelium and in the differentiation to SCC or ADC of the cervix.

KEYWORDS:

Pathology; adenocarcinoma; cervical intraepithelial neoplasia; human papillomavirus; squamous cell carcinoma; superoxide dismutase-2

Conflict of interest statement

CONFLICTS OF INTEREST L.L Villa is a consultant/advisory board member for Merck. No potential conflicts of interest were disclosed by the other authors.

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center