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Rev Esp Enferm Dig. 2019 Sep 30;111. doi: 10.17235/reed.2019.6085/2018. [Epub ahead of print]

The effect of Salvia miltiorrhiza in a mouse model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum.

Author information

1
Department of Gastroenterology, Hunan Provincial People's Hospital. Hunan Normal University. Changsh.
2
Department of Gastroenterology, The Second Xiangya Hospital. Central South University. Changsha, Hun.
3
Department of Gastroenterology, The Second Xiangya Hospital. Central South University.
4
Department of Gastroenterology, Hunan Provincial People's Hospital. Hunan Normal U, China.

Abstract

BACKGROUND AND AIMS:

to investigate the potential effect and mechanism of Salvia miltiorrhiza in Gynura segetum-induced hepatic sinusoidal obstruction syndrome (HSOS).

METHODS:

the mice were gavaged with PBS, Gynura segetum or Gynura segetum, along with 100 or 200 mg/kg Salvia miltiorrhiza. Histological scoring and liver function were performed. The expression of tumor necrosis factor-alpha (TNF-α), vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and nuclear transcription factor P65 (NF-κBp65) were determined by reverse transcriptase polymerase chain reaction (RT-PCR) and western blot.

RESULTS:

liver function were effectively improved in the Salvia miltiorrhiza groups. The levels of TNF-α, VCAM-1, ICAM-1 and NF-κBp65 were significantly lower in the Salvia miltiorrhiza groups than in the Gynura segetum group.

CONCLUSIONS:

Salvia miltiorrhiza has a therapeutic effect on Gynura segetum-induced HSOS.

PMID:
31566407
DOI:
10.17235/reed.2019.6085/2018
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