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PLoS One. 2018 Apr 3;13(4):e0192726. doi: 10.1371/journal.pone.0192726. eCollection 2018.

A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue.

Author information

1
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
2
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States of America.
3
Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, United States of America.
4
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.

Abstract

Over 26 million people worldwide suffer from heart failure annually. When the cause of heart failure cannot be identified, endomyocardial biopsy (EMB) represents the gold-standard for the evaluation of disease. However, manual EMB interpretation has high inter-rater variability. Deep convolutional neural networks (CNNs) have been successfully applied to detect cancer, diabetic retinopathy, and dermatologic lesions from images. In this study, we develop a CNN classifier to detect clinical heart failure from H&E stained whole-slide images from a total of 209 patients, 104 patients were used for training and the remaining 105 patients for independent testing. The CNN was able to identify patients with heart failure or severe pathology with a 99% sensitivity and 94% specificity on the test set, outperforming conventional feature-engineering approaches. Importantly, the CNN outperformed two expert pathologists by nearly 20%. Our results suggest that deep learning analytics of EMB can be used to predict cardiac outcome.

PMID:
29614076
PMCID:
PMC5882098
DOI:
10.1371/journal.pone.0192726
[Indexed for MEDLINE]
Free PMC Article

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