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Neurology. 2019 Feb 5;92(6):e594-e600. doi: 10.1212/WNL.0000000000006879. Epub 2019 Jan 9.

Association of body mass index and waist-to-hip ratio with brain structure: UK Biobank study.

Author information

1
From School Sport (M.H.), Exercise & Health Sciences, Loughborough University; and Department of Epidemiology and Public Health (M.H., G.D.B.), University College London, UK. m.hamer@lboro.ac.uk.
2
From School Sport (M.H.), Exercise & Health Sciences, Loughborough University; and Department of Epidemiology and Public Health (M.H., G.D.B.), University College London, UK.

Abstract

OBJECTIVE:

To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume.

METHODS:

We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced with structural MRI.

RESULTS:

After adjustment for a range of covariates, higher levels of all obesity measures were related to lower gray matter volume: BMI per 1 SD (β coefficient -4,113, 95% confidence interval [CI] -4,862 to -3,364), WHR (β coefficient -4,272, 95% CI -5,280 to -3,264), and fat mass (β coefficient -4,590, 95% CI -5,386 to -3,793). The combination of overall obesity (BMI ≥30 kg/m2) and central obesity (WHR >0.85 for women, >0.90 for men) was associated with the lowest gray matter compared with that in lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes, including caudate, putamen, pallidum, and nucleus accumbens. No associations between obesity and white matter were apparent.

CONCLUSION:

The combination of heightened BMI and WHR may be an important risk factor for gray matter atrophy.

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