Format

Send to

Choose Destination
Neurology. 2018 May 22;90(21):e1834-e1841. doi: 10.1212/WNL.0000000000005562. Epub 2018 Apr 25.

Involvement of the central somatosensory system in restless legs syndrome: A neuroimaging study.

Author information

1
From the Department of Radiology (B.-Y.L.), University of Minnesota, Minneapolis; Biomedical Engineering (J.K.), Duke University, Durham, NC; Departments of Neurosurgery (J.R.C.), Neurology (G.D.P.), and Radiology, Neurosurgery, and Bioengineering (Q.X.Y.), Pennsylvania State Hershey Medical Center; and Department of Radiological Science (Y.R.), Gachon University, South Korea. catchjoy73@gmail.com qyang@psu.edu.
2
From the Department of Radiology (B.-Y.L.), University of Minnesota, Minneapolis; Biomedical Engineering (J.K.), Duke University, Durham, NC; Departments of Neurosurgery (J.R.C.), Neurology (G.D.P.), and Radiology, Neurosurgery, and Bioengineering (Q.X.Y.), Pennsylvania State Hershey Medical Center; and Department of Radiological Science (Y.R.), Gachon University, South Korea.

Abstract

OBJECTIVE:

To investigate morphologic changes in the somatosensory cortex and the thickness of the corpus callosum subdivisions that provide interhemispheric connections between the 2 somatosensory cortical areas.

METHODS:

Twenty-eight patients with severe restless legs syndrome (RLS) symptoms and 51 age-matched healthy controls were examined with high-resolution MRI at 3.0 tesla. The vertex-wise analysis in conjunction with a novel cortical surface classification method was performed to assess the cortical thickness across the whole-brain structures. In addition, the thickness of the midbody of the corpus callosum that links postcentral gyri in the 2 hemispheres was measured.

RESULTS:

We demonstrated that a morphologic change occurred in the brain somatosensory system in patients with RLS compared to controls. Patients with RLS exhibited a 7.5% decrease in average cortical thickness in the bilateral postcentral gyrus (p < 0.0001). Accordingly, there was a substantial decrease in the corpus callosum posterior midbody (p < 0.008) wherein the callosal fibers are connected to the postcentral gyrus, suggesting altered white matter properties in the somatosensory pathway.

CONCLUSION:

Our results provide in vivo evidence of morphologic changes in the primary somatosensory system, which could be responsible for the sensory functional symptoms of RLS. These results provide a better understanding of the pathophysiology underlying the RLS sensory symptoms and could lead to a potential imaging marker for RLS.

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center