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J Glob Oncol. 2018 Sep;4:1-8. doi: 10.1200/JGO.17.00113. Epub 2017 Dec 27.

Assessment of Treatment Patterns for Metastatic Renal Cell Carcinoma in Brazil.

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Paulo G. Bergerot and Cristiane D. Bergerot, Universidade Federal de Sao Paulo; Stenio Zequi, Maria Nirvana Formiga, and Milena Shizue Tariki, A.C. Camargo Comprehensive Cancer Center; Edna Prado Gonçalves, Close-Up International, Sao Paulo; Andre Fay, PUCRS School of Medicine, Porto Alegre, Brazil; Paulo G. Bergerot, Cristiane D. Bergerot, Nazli Dizman, Yash Dara, Manuel Caitano Maia, Brendan N. Cotta, and Sumanta K. Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Diego Abreu Clavijo, Pasteur Hospital, Montevideo, Uruguay; Toni K. Choueiri, Dana-Farber Cancer Institute, Boston, MA; and Gilberto Lopes, University of Miami Sylvester Cancer Center, Miami, FL.



Although multiple therapies have emerged for the treatment of metastatic renal cell carcinoma (mRCC), it is unclear whether application of these agents is consistent in developed and developing countries. We sought to determine patterns of care for mRCC in Brazil as a representative developing country.


A commercial database was used to acquire information pertaining to patients with mRCC receiving treatment at private or public hospitals in Brazil between March 2013 and October 2016. Basic clinical and demographic criteria were available, as well as information to ascertain the International Metastatic Renal Cell Carcinoma Database Consortium risk. Treatment-related data across multiple lines of therapy were collected.


Of 4,379 patients assessed, 3,990 (91%) had metastatic disease, and 26%, 48%, and 26% of patients had good, intermediate, and poor International Metastatic Renal Cell Carcinoma Database Consortium risk disease, respectively. Although 3,149 patients (79%) received first-line therapy, only 641 (20%) and 152 (5%) received second- and third-line therapy, respectively. In the first-line setting, vascular endothelial growth factor-directed agents represented the most commonly used therapy, whereas in the second-line setting, vascular endothelial growth factor- and mammalian target of rapamycin-directed agents were used with similar frequency. Marked differences were seen in receipt of systemic therapy on the basis of treatment in private or public hospitals.


Relative to developed countries, marked attrition is noted between each subsequent line of therapy in Brazil. Patterns of care also vary greatly in private and public settings, pointing to financial constraints as a potential cause for discordances in treatment.

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