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Cancer Commun (Lond). 2019 Oct 1;39(1):53. doi: 10.1186/s40880-019-0402-8.

Pathological transition as the arising mechanism for drug resistance in lung cancer.

Chen Y1,2, Tang WY3, Tong X1,2, Ji H4,5.

Author information

1
State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P. R. China.
2
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
3
Sunway Medical Centre, 47500, Bandar Sunway, Selangor, Malaysia.
4
State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P. R. China. hbji@sibcb.ac.cn.
5
School of Life Science and Technology, Shanghai Tech University, Shanghai, 200120, P. R. China. hbji@sibcb.ac.cn.

Abstract

Despite the tremendous efforts for improving therapeutics of lung cancer patients, its prognosis remains disappointing. This can be largely attributed to the lack of comprehensive understanding of drug resistance leading to insufficient development of effective therapeutics in clinic. Based on the current progresses of lung cancer research, we classify drug resistance mechanisms into three different levels: molecular, cellular and pathological level. All these three levels have significantly contributed to the acquisition and evolution of drug resistance in clinic. Our understanding on drug resistance mechanisms has begun to change the way of clinical practice and improve patient prognosis. In this review, we focus on discussing the pathological changes linking to drug resistance as this has been largely overlooked in the past decades.

KEYWORDS:

Drug resistance; Lung cancer; Pathological transition

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