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Cancer Commun (Lond). 2018 Nov 26;38(1):69. doi: 10.1186/s40880-018-0341-9.

The 150 most important questions in cancer research and clinical oncology series: questions 94-101 : Edited by Cancer Communications.

Abstract

Since the beginning of 2017, Cancer Communications (former title: Chinese Journal of Cancer) has published a series of important questions regarding cancer research and clinical oncology, to provide an enhanced stimulus for cancer research, and to accelerate collaborations between institutions and investigators. In this edition, the following 8 valuable questions are presented. Question 94. The origin of tumors: time for a new paradigm? Question 95. How can we accelerate the identification of biomarkers for the early detection of pancreatic ductal adenocarcinoma? Question 96. Can we improve the treatment outcomes of metastatic pancreatic ductal adenocarcinoma through precision medicine guided by a combination of the genetic and proteomic information of the tumor? Question 97. What are the parameters that determine a competent immune system that gives a complete response to cancers after immune induction? Question 98. Is high local concentration of metformin essential for its anti-cancer activity? Question 99. How can we monitor the emergence of cancer cells anywhere in the body through plasma testing? Question 100. Can phytochemicals be more specific and efficient at targeting P-glycoproteins to overcome multi-drug resistance in cancer cells? Question 101. Is cell migration a selectable trait in the natural evolution of carcinoma?

KEYWORDS:

Biomarker; Chemotherapy; Circulating tumor DNA; Circulating tumor cell; CpG methylation; Epithelial-to-mesenchymal transition; Immunotherapy; Liquid biopsy; Metastasis; Metformin; Methylation haplotype block; Migration; Multi-drug resistance; P-Glycoprotein; P-Glycoprotein inhibitor; Pancreatic ductal adenocarcinoma; Phytochemicals; Polyploid giant cancer cell; Precision treatment; Pro-migratory gene; Spontaneous animal model; Tumor origin; Vaccine immunization

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