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Diagn Pathol. 2018 Jan 25;13(1):10. doi: 10.1186/s13000-018-0688-x.

Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report.

Author information

1
Department of Anatomic Pathology, A.C. Camargo Cancer Center, 211 Professor Antônio Prudente Street, Sao Paulo, Zip code 01509-900, Brazil. ricardopastorello@hotmail.com.
2
Department of Anatomic Pathology, A.C. Camargo Cancer Center, 211 Professor Antônio Prudente Street, Sao Paulo, Zip code 01509-900, Brazil.
3
Department of Breast Surgery, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
4
Department of Breast Surgery, A.C. Camargo Cancer Center, University of São Paulo, Sao Paulo, Brazil.

Abstract

BACKGROUND:

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been published on this entity in recent years, a great number of patients and health professionals remain unaware of this diagnosis.

CASE PRESENTATION:

We herein report the case of a 56-year-old female with Li-FRAUMENI syndrome who presented with late right-sided recurrent breast swelling after prophylactic adenomastectomy with implant reconstruction. Imaging scans revealed an heterogeneous mass adjacent to the implant fibrous capsule. A biopsy of the lesion rendered the diagnosis of a BIA-ALCL.

CONCLUSIONS:

This case presents similarities with previous reports, but also some particularities, which should be stressed in order to make the diagnosis the earliest possible. The most distinct feature is that this is the second report of BIA-ALCL arising in the setting of Li-FRAUMENI syndrome.

KEYWORDS:

Anaplastic large cell lymphoma; Anaplastic lymphoma kinase (ALK); Breast implant; Li-FRAUMENI syndrome; Lymphoma

PMID:
29370815
PMCID:
PMC5784673
DOI:
10.1186/s13000-018-0688-x
[Indexed for MEDLINE]
Free PMC Article

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