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World J Surg Oncol. 2018 Nov 12;16(1):221. doi: 10.1186/s12957-018-1520-5.

Dedifferentiated liposarcoma of the gallbladder: first reported case.

Author information

1
Oncological Surgery Unit, Napoleão Laureano Hospital, Av. Flamboyant, 198, Anatólia, João Pessoa, PB, 58052-010, Brazil. adrianocacosta@gmail.com.
2
School of Medicine, Federal University of Pernambuco, Recife, PE, Brazil.
3
Harvard T.H. Chan School of Public Health, Boston, MA, USA.
4
Department of Sarcoma, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
5
School of Medicine, Faculty of Medical Sciences of Paraíba, João Pessoa, PB, Brazil.
6
Department of Pathology, Napoleão Laureano Hospital, João Pessoa, PB, Brazil.
7
Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil.

Abstract

BACKGROUND:

Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge.

CASE PRESENTATION:

A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. The CT report suggested gallbladder liposarcoma. A cholecystectomy associated with resection of segments IV-B and V of the liver were performed. Intraoperative frozen sections were compatible with gallbladder sarcoma. Anatomopathological examination and immunohistochemistry confirmed dedifferentiated liposarcoma with foci of heterologous leiomyosarcomatous differentiation and undifferentiated fusocellular areas of high histological grade.

CONCLUSION:

This is the first case of dedifferentiated liposarcoma of the gallbladder to be reported.

KEYWORDS:

Dedifferentiated liposarcoma; Gallbladder disease; Gallbladder neoplasms; Immunohistochemistry; Liposarcoma

PMID:
30419915
PMCID:
PMC6233360
DOI:
10.1186/s12957-018-1520-5
[Indexed for MEDLINE]
Free PMC Article

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