Format

Send to

Choose Destination
Am J Respir Crit Care Med. 2019 Mar 29. doi: 10.1164/rccm.201808-1474OC. [Epub ahead of print]

Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children.

Author information

1
Johns Hopkins University, 1466, Pulmonary and Critical Care, Baltimore, Maryland, United States ; epfeil1@jhmi.edu.
2
Johns Hopkins University, 1466, Pulmonary and Critical Care, Baltimore, Maryland, United States.
3
Johns Hopkins University, Pulmonary and Critical Care, Baltimore, Maryland, United States.
4
Johns Hopkins, Baltimore, Maryland, United States.
5
Johns Hopkins University Bloomberg School of Public Health, 25802, Baltimore, Maryland, United States.
6
Florida International University College of Arts Sciences and Education, 123383, Miami, Florida, United States.
7
Johns Hopkins School of Medicine, 1500, Department of Medicine, Baltimore, Maryland, United States.
8
Johns Hopkins University, 1466, Baltimore, Maryland, United States.
9
University of Alberta Hospital, 25484, Medicine, Edmonton, Alberta, Canada.
10
University of Alberta, Department of Medicine, Edmonton, Alberta, Canada.
11
Icahn School of Medicine at Mount Sinai, 5925, Division of Pulmonary, Sleep, and Critical Care Medicine, New York, New York, United States.
12
Icahn School of Medicine at Mount Sinai, 5925, Pediatrics, New York, New York, United States.
13
University of Nebraska Medical Center, Medical Nutrition Education, Omaha, Nebraska, United States.
14
The Johns Hopkins University, Division of Pulmonary Critical Care, Department of Medicine, Baltmore, Maryland, United States.
15
A.B. PRISMA, Biomedical Research Unit, Lima, Peru.
16
John Hopkins Hospital, Baltimore, Maryland, United States.
17
Johns Hopkins University, Medicine, Baltimore, Maryland, United States.

Abstract

RATIONALE:

Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also linked with asthma outcomes, may influence this relationship.

OBJECTIVES:

Determine (1) the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity, and (2) the association between fatty acid intake and strength of indoor, PM-related asthma symptoms, albuterol use, and systemic inflammation.

METHODS:

Analyses included 135 children with asthma enrolled in the AsthmaDIET Study. At baseline, 3, and 6 months, data included: week-long average home indoor concentration of PM2.5 and PM10, dietary intake of omega-3 and omega-6 fatty acids, daily symptoms, and peripheral blood leukocytes. Asthma severity and lung function were assessed at baseline. Multivariable regression models, adjusted for known confounders, were used to determine associations between each fatty acid and outcomes of interest, with interaction terms (fatty acids x PM) in longitudinal analyses.

MEASUREMENTS AND MAIN RESULTS:

Higher omega-6 intake associated with increased odds of increased asthma severity (p=0.02), and lower FEV1/FVC ratio (p=0.01). Higher omega-3 intake associated with reduced effect of indoor PM2.5 on symptoms (p<0.01), while higher omega-6 intake associated with amplified effect of indoor PM2.5 on symptoms and circulating neutrophil percentage (p<0.01).

CONCLUSIONS:

Omega-3 and omega-6 intake are associated with pediatric asthma morbidity, and may modify the asthmatic response to indoor PM.

KEYWORDS:

Diet; Inflammation; Particulate Matter

PMID:
30922077
DOI:
10.1164/rccm.201808-1474OC

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center