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Cancer Res. 2019 Mar 15;79(6):1044-1046. doi: 10.1158/0008-5472.CAN-18-3437. Epub 2019 Feb 25.

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy.

Author information

1
Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
2
Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia.
3
Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
4
Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia. david.gewirtz@vcuhealth.org.

Abstract

Senescence, a durable form of growth arrest, represents a primary response to numerous anticancer therapies. Although the paradigm that senescence is "irreversible" has largely withstood the findings of tumor cell recovery from what has been termed "pseudo-senescence" or "senescence-like arrest," a review of the literature suggests that therapy-induced senescence in tumor cells is not obligatorily a permanent cell fate. Consequently, we propose that senescence represents one avenue whereby tumor cells evade the direct cytotoxic impact of therapy, thereby allowing for prolonged survival in a dormant state, with the potential to recover self-renewal capacity and contribute to disease recurrence.

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