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Science. 2019 Mar 1;363(6430):989-993. doi: 10.1126/science.aaw2586.

A lipase-independent pathway of lipid release and immune modulation by adipocytes.

Author information

1
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, NY 07043, USA.
2
Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA.
3
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, NY 07043, USA. awf7@columbia.edu.
#
Contributed equally

Abstract

To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a secondary pathway of lipid release from adipocytes that is independent of canonical lipolysis. We found that adipocytes release exosome-sized, lipid-filled vesicles (AdExos) that become a source of lipid for local macrophages. Adipose tissue from lean mice released ~1% of its lipid content per day via exosomes ex vivo, a rate that more than doubles in obese animals. AdExos and associated factors were sufficient to induce in vitro differentiation of bone marrow precursors into adipose tissue macrophage-like cells. Thus, AdExos are both an alternative pathway of local lipid release and a mechanism by which parenchymal cells can modulate tissue macrophage differentiation and function.

PMID:
30819964
DOI:
10.1126/science.aaw2586

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