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Science. 2019 Apr 19;364(6437). pii: eaav8736. doi: 10.1126/science.aav8736. Epub 2019 Apr 18.

Amygdala ensembles encode behavioral states.

Author information

1
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland. jan.grundemann@unibas.ch andreas.luthi@fmi.ch.
2
Department of Biomedicine, University of Basel, Klingelbergstrasse 50-70, Basel, Switzerland.
3
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland.
4
Institute of Neuroinformatics, University and ETH Zürich, Winterthurerstrasse 190, Zürich, Switzerland.
5
Department of Electrical Engineering and Information Technology, ETH Zürich, Switzerland.
6
Howard Hughes Medical Institute, CNC Program, James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, CA, USA.
7
University of Basel, 4000 Basel, Switzerland.
#
Contributed equally

Abstract

Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By longitudinally imaging neural calcium dynamics in freely moving mice across different environments, we identified opponent changes in activity levels of two major, nonoverlapping populations of basal amygdala principal neurons. This population signature does not report global anxiety but predicts switches between exploratory and nonexploratory, defensive states. Moreover, the amygdala separately processes external stimuli and internal states and broadcasts state information via several output pathways to larger brain networks. Our findings extend the concept of thalamocortical "brain-state" coding to include affective and exploratory states and provide an entry point into the state dependency of brain function and behavior in defined circuits.

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PMID:
31000636
DOI:
10.1126/science.aav8736
[Indexed for MEDLINE]

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