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Eur J Neurosci. 2019 Jul 25. doi: 10.1111/ejn.14529. [Epub ahead of print]

Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets.

Author information

1
Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Japan.
2
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
3
Faculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney, NSW, Australia.
4
Australian Research Council Centre of Excellence for Integrative Brain Function, Sydney University Node, Sydney, NSW, Australia.
5
Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
6
Integra Life Science Japan, Minato-Ku, Akasaka, Japan.
7
Systems Neuroscience Institute and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
8
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
9
Department of Physiology and Biomedicine Research Institute, Monash University, Clayton, Vic., Australia.
10
Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University Node, Clayton, Vic., Australia.
11
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Abstract

Traditionally, the dorsal lateral geniculate nucleus (LGN) and the inferior pulvinar (IPul) nucleus are considered as anatomically and functionally distinct thalamic nuclei. However, in several primate species it has also been established that the koniocellular (K) layers of LGN and parts of the IPul have a shared pattern of immunoreactivity for the calcium-binding protein calbindin. These calbindin-rich cells constitute a thalamic matrix system which is implicated in thalamocortical synchronisation. Further, the K layers and IPul are both involved in visual processing and have similar connections with retina and superior colliculus. Here, we confirmed the continuity between calbindin-rich cells in LGN K layers and the central lateral division of IPul (IPulCL) in marmoset monkeys. By employing a high-throughput neuronal tracing method, we found that both the K layers and IPulCL form comparable patterns of connections with striate and extrastriate cortices; these connections are largely different to those of the parvocellular and magnocellular laminae of LGN. Retrograde tracer-labelled cells and anterograde tracer-labelled axon terminals merged seamlessly from IPulCL into LGN K layers. These results support continuity between LGN K layers and IPulCL, providing an anatomical basis for functional congruity of this region of the dorsal thalamic matrix and calling into question the traditional segregation between LGN and the inferior pulvinar nucleus.

KEYWORDS:

lateral geniculate; pulvinar; thalamic matrix; visual pathway

PMID:
31344282
DOI:
10.1111/ejn.14529

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