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Ann N Y Acad Sci. 2014 Sep;1323:22-42. doi: 10.1111/nyas.12537.

Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management.

Author information

1
Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Israel.

Abstract

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.

KEYWORDS:

antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; carbapenemases; infection control; molecular genetics; treatment

PMID:
25195939
DOI:
10.1111/nyas.12537
[Indexed for MEDLINE]

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