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J Oral Pathol Med. 2018 Jan;47(1):32-39. doi: 10.1111/jop.12601. Epub 2017 Aug 4.

Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients.

Author information

1
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
2
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, The University of Sheffield, Sheffield, UK.
3
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
4
Department of Anatomic Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
5
Departament of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista, São José dos Campos, Brazil.
6
Oral Pathology and Oral Medicine, Dentistry School, Western Paraná State University, Cascavel, Brazil.
7
Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.

Abstract

OBJECTIVES:

Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide, and the clinical and behavioral characteristics of tumors in this group are controversial, and the literature shows divergent results.

PURPOSE:

To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤40 years old).

METHODS:

A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies.

RESULTS:

Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (P=.042) and MMP-9 (P=.001) was more frequent in young patients, only C-ErbB-2 (P=.048) and SMA (P=.048) expression correlated with lower disease-free survival (DFS) in this group of patients.

CONCLUSION:

Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9, and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.

KEYWORDS:

cell cycle proteins; clinicopathologic characteristics; local invasion proteins; oral squamous cell carcinoma

PMID:
28626969
DOI:
10.1111/jop.12601
[Indexed for MEDLINE]
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