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J Cutan Pathol. 2018 Feb;45(2):141-145. doi: 10.1111/cup.13062. Epub 2017 Nov 27.

Leiomyosarcoma of the great saphenous vein (vena saphena magna) with granular cell change: Report of a superficial neoplasm.

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Department of Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Department of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
Orthopedic Oncology Department, Hospital Israelita Albert Einstein, Centro de Oncologia e Hematologia Família Dayan Daycoval, São Paulo, Brazil.


The great saphenous vein (GSV) corresponds to the main superficial large-caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular soft tissue mass. Herein, we report a case on the distal portion of the right GSV of a 57-year-old man. The histopathological recognition of a large-caliber vein-associated LMS (with granular cell change) in an incisional biopsy specimen was crucial to guide radiological evaluation and confirmation of a superficial vascular LMS before surgical treatment. Recognizing this entity in small biopsies is important as its surgical treatment and prognosis differ substantially from nonvascular superficial (ie, subcutaneous and dermal) LMSs. In addition, because vascular LMSs can involve long vessel segments, underestimation of extent of disease is a risk. To the best of our knowledge, granular cell change has not been documented in LMS of the GSV.


granular cell change; great saphenous vein leiomyosarcoma; large-caliber vessel leiomyosarcoma; superficial leiomyosarcoma sarcoma; vascular leiomyosarcoma

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