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Am J Transplant. 2018 Sep;18(9):2220-2228. doi: 10.1111/ajt.15022. Epub 2018 Aug 13.

Long-term outcomes of transmesenteric portal vein recanalization for the treatment of chronic portal vein thrombosis after pediatric liver transplantation.

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Interventional Radiology Unit, A. C. Camargo Cancer Center Hospital, São Paulo, Brazil.
Interventional Radiology Unit, Hospital Sirio-Libanês, São Paulo, Brazil.
Liver Transplantation Unit, A. C. Camargo Cancer Center Hospital, São Paulo, Brazil.
Liver Transplantation Unit, Hospital Sirio-Libanês, São Paulo, Brazil.


Portal vein thrombosis (PVT) may occur at any time following liver transplantation. We describe our experience with portal vein recanalization in cases of thrombosis after liver transplantation. Twenty-eight children (5%) out of 566 liver transplant recipients underwent portal vein recanalization using a transmesenteric approach. All children received left hepatic segments, developed PVT, and had symptoms or signs of portal hypertension. Portal vein recanalization was performed via the transmesenteric route in all cases. Twenty-two (78.6%) patients underwent successful recanalization and stent placement. They received oral anticoagulants after the procedure, and clinical symptoms subsided. Symptoms recurred due to portal vein restenosis/thrombosis in seven patients. On an intention-to-treat basis, the success rate of the proposed treatment was 60.7%. Only 17 out of 28 children with posttransplant chronic PVT retained stent patency (primary + assisted) at the end of the study period. In cases of portal vein obstruction, the transmesenteric approach via minilaparotomy is technically feasible with good clinical and hemodynamic results. It is an alternative procedure to reestablish the portal flow to the liver graft that can be performed in selected cases and a therapeutic addition to other treatment strategies currently used to treat chronic PVT.


clinical research/practice; complication: surgical/technical; liver transplantation/hepatology; liver transplantation: living donor; pediatrics; thrombosis and thromboembolism


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