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Biol Lett. 2019 Jul 26;15(7):20190374. doi: 10.1098/rsbl.2019.0374. Epub 2019 Jul 10.

The origin of platelets enabled the evolution of eutherian placentation.

Martin JF1,2, Wagner GP3,4,5,6.

Author information

1
1 Division of Medicine, University College London , London WC1E 6JF , UK.
2
2 Internal Medicine, Gynecology and Reproductive Sciences, Yale School of Medicine , New Haven, CT 06520 , USA.
3
3 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine , New Haven, CT 06520 , USA.
4
4 Department of Ecology and Evolutionary Biology, Yale University , CT 06520 , USA.
5
5 Systems Biology Institute , Yale West Campus, West Haven, CT 06516 , USA.
6
6 Department of Obstetrics and Gynecology, Wayne State University , Detroit, MI 48202 , USA.

Abstract

Invasive placentation with extended pregnancy is a shared derived characteristic unique to eutherian mammals that possess a highly effective system of haemostasis, platelets. These are found in all mammals but no other group of animals. We propose that platelets and megakaryocytes (large polyploid nucleated bone marrow cells that produce platelets) evolved from an ancestral 2 N thrombocyte by polyploidization and that the possession of platelets enabled the evolution of invasive placentation. This could explain why invasive placentation is limited to mammals.

KEYWORDS:

evolution; mammal; megakaryocyte; placenta; platelet

PMID:
31288683
DOI:
10.1098/rsbl.2019.0374

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