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Appl Immunohistochem Mol Morphol. 2018 Feb;26(2):120-125. doi: 10.1097/PAI.0000000000000397.

MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.

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Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation.
School of Medicine of the Federal University of Minas Gerais, Minas Gerais.
AC Camargo Cancer Center, São Paulo, Brazil.
Aristides Maltez Hospital.
Laboratory of Oral Surgical Pathology, School of Dentistry of the Federal University of Bahia.
Department of Pathology, School of Medicine of Federal University of Bahia, Bahia.


The present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation. Twenty-eight cases of OSCC, 9 of tumor-free resection margins (TM), and 4 of non-neoplastic oral mucosa (NNM) were subjected to immunohistochemistry to detect the expression of proteins MCM3 and Ki-67. All OSCCs demonstrated positivity for both proteins. In these tumors, greater MCM3 immunoreactivity was observed in comparison with Ki-67, whereas TMs and NNMs exhibited greater Ki-67 expression compared with MCM3. The immunoexpression of Ki-67 seemed to be influenced by the inflammatory process, particularly in TM and NNM. Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors.

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