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Appl Immunohistochem Mol Morphol. 2018 Feb;26(2):120-125. doi: 10.1097/PAI.0000000000000397.

MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.

Author information

1
Laboratory of Pathology and Molecular Biology, Oswaldo Cruz Foundation.
2
School of Medicine of the Federal University of Minas Gerais, Minas Gerais.
3
AC Camargo Cancer Center, São Paulo, Brazil.
4
Aristides Maltez Hospital.
5
Laboratory of Oral Surgical Pathology, School of Dentistry of the Federal University of Bahia.
6
Department of Pathology, School of Medicine of Federal University of Bahia, Bahia.

Abstract

The present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation. Twenty-eight cases of OSCC, 9 of tumor-free resection margins (TM), and 4 of non-neoplastic oral mucosa (NNM) were subjected to immunohistochemistry to detect the expression of proteins MCM3 and Ki-67. All OSCCs demonstrated positivity for both proteins. In these tumors, greater MCM3 immunoreactivity was observed in comparison with Ki-67, whereas TMs and NNMs exhibited greater Ki-67 expression compared with MCM3. The immunoexpression of Ki-67 seemed to be influenced by the inflammatory process, particularly in TM and NNM. Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors.

PMID:
27258565
DOI:
10.1097/PAI.0000000000000397
[Indexed for MEDLINE]

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