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Proc Natl Acad Sci U S A. 2018 May 22;115(21):5377-5382. doi: 10.1073/pnas.1719573115. Epub 2018 May 7.

Wireless, intraoral hybrid electronics for real-time quantification of sodium intake toward hypertension management.

Author information

1
George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
2
Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284.
3
Department of Chemical and Biomolecular Engineering, Chonnam National University, 59626 Jeonnam, South Korea.
4
Department of Prosthodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298.
5
Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA 15261.
6
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261.
7
Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
8
George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA 30332; whyeo@gatech.edu.
9
Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332.
10
Petit Institute for Bioengineering & Bioscience, Georgia Institute of Technology, Atlanta, GA 30332.
11
Center for Flexible Electronics, Georgia Institute of Technology, Atlanta, GA 30332.

Abstract

Recent wearable devices offer portable monitoring of biopotentials, heart rate, or physical activity, allowing for active management of human health and wellness. Such systems can be inserted in the oral cavity for measuring food intake in regard to controlling eating behavior, directly related to diseases such as hypertension, diabetes, and obesity. However, existing devices using plastic circuit boards and rigid sensors are not ideal for oral insertion. A user-comfortable system for the oral cavity requires an ultrathin, low-profile, and soft electronic platform along with miniaturized sensors. Here, we introduce a stretchable hybrid electronic system that has an exceptionally small form factor, enabling a long-range wireless monitoring of sodium intake. Computational study of flexible mechanics and soft materials provides fundamental aspects of key design factors for a tissue-friendly configuration, incorporating a stretchable circuit and sensor. Analytical calculation and experimental study enables reliable wireless circuitry that accommodates dynamic mechanical stress. Systematic in vitro modeling characterizes the functionality of a sodium sensor in the electronics. In vivo demonstration with human subjects captures the device feasibility for real-time quantification of sodium intake, which can be used to manage hypertension.

KEYWORDS:

hypertension management; sodium intake quantification; stretchable hybrid electronics; wireless intraoral system

PMID:
29735689
DOI:
10.1073/pnas.1719573115
[Indexed for MEDLINE]
Free PMC Article

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