Format

Send to

Choose Destination
Lab Chip. 2019 Feb 4. doi: 10.1039/c8lc01200h. [Epub ahead of print]

Modular soft robotic microdevices for dexterous biomanipulation.

Author information

1
Institute of Mechanical Engineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. selman.sakar@epfl.ch and Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Massachusetts 02138, USA.
2
Institute of Mechanical Engineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. selman.sakar@epfl.ch.
3
Institute of Materials Science and Engineering, EPFL, CH-1015 Lausanne, Switzerland.
4
Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Massachusetts 02138, USA.

Abstract

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransducers, and in situ polymerization of compliant hydrogel mechanisms. We synthesize optomechanical microactuators using a template-assisted microfluidic approach in which gold nanorods coated with thermoresponsive poly(N-isopropylmethacrylamide) (pNIPMAM) polymer function as nanoscale building blocks. The resulting microactuators exhibit mechanical properties (4.8 ± 2.1 kPa stiffness) and performance metrics (relative stroke up to 0.3 and stress up to 10 kPa) that are comparable to that of bioengineered muscular constructs. Near-infrared (NIR) laser illumination provides effective spatiotemporal control over actuation (sub-micron spatial resolution at millisecond temporal resolution). Spatially modulated hydrogel photolithography guided by an experimentally validated finite element-based design methodology allows construction of compliant poly(ethylene glycol) diacrylate (PEGDA) mechanisms around the microactuators. We demonstrate the versatility of our approach by manufacturing a diverse array of microdevices including lever arms, continuum microrobots, and dexterous microgrippers. We present a microscale compression device that is developed for mechanical testing of three-dimensional biological samples such as spheroids under physiological conditions.

PMID:
30714604
DOI:
10.1039/c8lc01200h

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center