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Chem Commun (Camb). 2013 May 10;49(37):3833-5. doi: 10.1039/c3cc38688k.

Directed evolution of a synthetic RNA-protein module to create a new translational switch.

Author information

1
Laboratory of Gene Biodynamics, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Kyoto, 606-8502, Japan.

Abstract

A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.

PMID:
23381780
DOI:
10.1039/c3cc38688k
[Indexed for MEDLINE]

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