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Sci Rep. 2018 Mar 28;8(1):5341. doi: 10.1038/s41598-018-23424-0.

Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease.

Author information

1
Mathematical Sciences, University of Southampton, Southampton, UK.
2
Faculty of Health Sciences, University of Southampton, Southampton, UK.
3
NIHR Southampton Respiratory and Critical Care Biomedical Research Centre. University of Southampton, Southampton, UK.
4
Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK.
5
Mathematical Sciences, University of Southampton, Southampton, UK. J.Brodzki@soton.ac.uk.

Abstract

Quantitative features that can currently be obtained from medical imaging do not provide a complete picture of Chronic Obstructive Pulmonary Disease (COPD). In this paper, we introduce a novel analytical tool based on persistent homology that extracts quantitative features from chest CT scans to describe the geometric structure of the airways inside the lungs. We show that these new radiomic features stratify COPD patients in agreement with the GOLD guidelines for COPD and can distinguish between inspiratory and expiratory scans. These CT measurements are very different to those currently in use and we demonstrate that they convey significant medical information. The results of this study are a proof of concept that topological methods can enhance the standard methodology to create a finer classification of COPD and increase the possibilities of more personalized treatment.

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