Format

Send to

Choose Destination
Sci Rep. 2018 Feb 2;8(1):2320. doi: 10.1038/s41598-018-20794-3.

Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff.

Author information

1
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
2
Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory Uppsala University, Uppsala, Sweden.
3
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. bethany.vanguelpen@umu.se.

Abstract

Lifestyle behaviors are believed to influence the body's inflammatory state. Chronic low-grade inflammation contributes to the development of major non-communicable diseases such as diabetes, cardiovascular disease and cancer. Inflammation may thus be an important link between lifestyle and disease. We evaluated self-reported physical activity, tobacco use and alcohol consumption in relation to plasma levels of 160 validated inflammatory and cancer biomarkers. The study included 138 participants from a population-based cohort, all with repeated sampling of plasma and data ten years apart, allowing consideration of both intra- and inter-individual variation. Of 17 relationships identified, the strongest was an independent, positive association between cornulin (CRNN) and Swedish moist snuff (snus) use. We replicated the finding in a second cohort of 501 individuals, in which a dose-response relationship was also observed. Snus explained approximately one fifth of the variance in CRNN levels in both sample sets (18% and 23%). In conclusion, we identified a novel, independent, dose-dependent association between CRNN and snus use. Further study is warranted, to evaluate the performance of CRNN as a potential snus biomarker. The putative importance of lifestyle behaviors on a wide range of protein biomarkers illustrates the need for more personalized biomarker cut-offs.

PMID:
29396534
PMCID:
PMC5797131
DOI:
10.1038/s41598-018-20794-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center