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Nat Ecol Evol. 2019 Apr 8. doi: 10.1038/s41559-019-0866-6. [Epub ahead of print]

Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season.

Author information

1
Division of Seasonal Biology, National Institute for Basic Biology, Okazaki, Japan.
2
Laboratory of Animal Integrative Physiology, Nagoya University, Nagoya, Japan.
3
Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), Miura, Japan.
4
Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
5
Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Japan.
6
Laboratory of Bioresources, National Institute for Basic Biology, Okazaki, Japan.
7
Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Nagahama, Japan.
8
Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
9
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan.
10
Spectrography and Bioimaging Facility, National Institute for Basic Biology, Okazaki, Japan.
11
Division of Seasonal Biology, National Institute for Basic Biology, Okazaki, Japan. takashiy@agr.nagoya-u.ac.jp.
12
Laboratory of Animal Integrative Physiology, Nagoya University, Nagoya, Japan. takashiy@agr.nagoya-u.ac.jp.
13
Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Japan. takashiy@agr.nagoya-u.ac.jp.
14
Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. takashiy@agr.nagoya-u.ac.jp.

Abstract

To cope with seasonal environmental changes, animals adapt their physiology and behaviour in response to photoperiod. However, the molecular mechanisms underlying these adaptive changes are not completely understood. Here, using genome-wide expression analysis, we show that an uncharacterized long noncoding RNA (lncRNA), LDAIR, is strongly regulated by photoperiod in Japanese medaka fish (Oryzias latipes). Numerous transcripts and signalling pathways are activated during the transition from short- to long-day conditions; however, LDAIR is one of the first genes to be induced and its expression shows a robust daily rhythm under long-day conditions. Transcriptome analysis of LDAIR knockout fish reveals that the LDAIR locus regulates a gene neighbourhood, including corticotropin releasing hormone receptor 2, which is involved in the stress response. Behavioural analysis of LDAIR knockout fish demonstrates that LDAIR affects self-protective behaviours under long-day conditions. Therefore, we propose that photoperiodic regulation of corticotropin releasing hormone receptor 2 by LDAIR modulates adaptive behaviours to seasonal environmental changes.

PMID:
30962562
DOI:
10.1038/s41559-019-0866-6

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