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Nat Commun. 2019 May 24;10(1):2307. doi: 10.1038/s41467-019-10290-1.

Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan.

Author information

1
Departments of Chemistry, Chemical Engineering, Materials Science & Engineering, and The Laboratory for Synthetic-Biologic Interactions, Texas A&M University, College Station, TX, 77842-3012, USA.
2
Department of Surgery, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
3
Departments of Chemistry, Chemical Engineering, Materials Science & Engineering, and The Laboratory for Synthetic-Biologic Interactions, Texas A&M University, College Station, TX, 77842-3012, USA. wooley@chem.tamu.edu.
4
Departments of Chemistry, Chemical Engineering, Materials Science & Engineering, and The Laboratory for Synthetic-Biologic Interactions, Texas A&M University, College Station, TX, 77842-3012, USA. mahmoud.elsabahy@chem.tamu.edu.
5
Department of Pharmaceutics and Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, 71515, Egypt. mahmoud.elsabahy@chem.tamu.edu.
6
Misr University for Science and Technology, 6th of October City, 12566, Egypt. mahmoud.elsabahy@chem.tamu.edu.

Abstract

The development of hemostatic technologies that suit a diverse range of emergency scenarios is a critical initiative, and there is an increasing interest in the development of absorbable dressings that can be left in the injury site and degrade to reduce the duration of interventional procedures. In the current study, β-cyclodextrin polyester (CDPE) hydrogels serve as sacrificial macroporous carriers, capable of degradation under physiological conditions. The CDPE template enables the assembly of imprinted chitosan honeycomb-like monolithic mats, containing highly entangled nanofibers with diameters of 9.2 ± 3.7 nm, thereby achieving an increase in the surface area of chitosan to improve hemostatic efficiency. In vivo, chitosan-loaded cyclodextrin (CDPE-Cs) hydrogels yield significantly lower amounts of blood loss and shorter times to hemostasis compared with commercially available absorbable hemostatic dressings, and are highly biocompatible. The designed hydrogels demonstrate promising hemostatic efficiency, as a physiologically-benign approach to mitigating blood loss in tissue-injury scenarios.

PMID:
31127114
PMCID:
PMC6534699
DOI:
10.1038/s41467-019-10290-1
[Indexed for MEDLINE]
Free PMC Article

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