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Nat Commun. 2019 Apr 3;10(1):1503. doi: 10.1038/s41467-019-09558-3.

Recollection in the human hippocampal-entorhinal cell circuitry.

Author information

1
School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK. b.staresina@bham.ac.uk.
2
Centre for Human Brain Health, University of Birmingham, Birmingham, B15 2TT, UK. b.staresina@bham.ac.uk.
3
Deptartment of Epileptology, University of Bonn Medical Centre, Bonn, D- 53175, Germany.
4
Faculty of Psychology, Swiss Distance Learning University, Brig, 3900, Switzerland.
5
Department of Neurosurgery, University of Bonn Medical Centre, Bonn, D- 53175, Germany.

Abstract

Imagine how flicking through your photo album and seeing a picture of a beach sunset brings back fond memories of a tasty cocktail you had that night. Computational models suggest that upon receiving a partial memory cue ('beach'), neurons in the hippocampus coordinate reinstatement of associated memories ('cocktail') in cortical target sites. Here, using human single neuron recordings, we show that hippocampal firing rates are elevated from ~ 500-1500 ms after cue onset during successful associative retrieval. Concurrently, the retrieved target object can be decoded from population spike patterns in adjacent entorhinal cortex (EC), with hippocampal firing preceding EC spikes and predicting the fidelity of EC object reinstatement. Prior to orchestrating reinstatement, a separate population of hippocampal neurons distinguishes different scene cues (buildings vs. landscapes). These results elucidate the hippocampal-entorhinal circuit dynamics for memory recall and reconcile disparate views on the role of the hippocampus in scene processing vs. associative memory.

PMID:
30944325
PMCID:
PMC6447634
DOI:
10.1038/s41467-019-09558-3
[Indexed for MEDLINE]
Free PMC Article

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