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Light Sci Appl. 2019 Jan 16;8:7. doi: 10.1038/s41377-018-0117-7. eCollection 2019.

Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging.

Author information

1
1Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA.
2
2Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 USA.

Abstract

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.

Conflict of interest statement

J.A.W. and V.B. have submitted a provisional patent on SC-OCTA. All the remaining authors declare that they have no conflict of interest.

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