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Sci Rep. 2018 Jan 30;8(1):1849. doi: 10.1038/s41598-018-20133-6.

Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population.

Author information

1
Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil. ahcampos@accamargo.org.br.
2
Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
3
Department of Collective Health, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil.
4
Department of Anatomic Pathology, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil.
5
Department of Anatomic Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
6
Hematology Clinics, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil.
7
Department of Anatomic Pathology, Hospital do Câncer de Barretos, São Paulo, Brazil.
8
DASA - Diagnósticos das Américas, Barueri-SP, Brazil.
9
Pathology - D'Or Hospitals Network e Faculty of Dentristry, USP, São Paulo, Brazil.
10
Laboratory of Investigative Pathology, CIPED, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil.

Abstract

The epidemiology of classical Hodgkin lymphoma varies significantly in populations with different socioeconomic conditions. Among other changes, improvement in such conditions leads to a reduction in the association with EBV infection and predominance of the nodular sclerosis subtype. This study provides an overview of the epidemiology of 817 cases of classical Hodgkin lymphoma diagnosed in five reference hospitals of the State of Sao Paulo, Brazil, over 54 years (1954-2008). The cases were distributed in 3 periods (1954-1979; 1980-1999; and 2000-2008). EBV-positive cases decreased from 87% to 46%. In children and adolescents (<15 years) and in young adults (15-45 years), EBV-positive cases decreased respectively from 96% to 64%, and from 85% to 32%. The percentage of male patients declined from 80% to 58%. In older patients (>45 years), the decrease in EBV infection was not significant. Nodular Sclerosis was the most common subtype in all periods. These results support the hypothesis that, in the Brazilian State of Sao Paulo, classical Hodgkin lymphoma has changed and now shows characteristics consistent with Pattern III observed in populations that experienced a similar socioeconomic transition.

PMID:
29382865
PMCID:
PMC5789833
DOI:
10.1038/s41598-018-20133-6
[Indexed for MEDLINE]
Free PMC Article

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