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ACS Chem Biol. 2018 May 18;13(5):1165-1172. doi: 10.1021/acschembio.8b00309. Epub 2018 Apr 20.

Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.

Author information

1
Department of Chemistry , Clemson University , Clemson , South Carolina 29634 , United States.
2
Department of Biological Sciences , Clemson University , Clemson , South Carolina 29634 , United States.

Abstract

A new approach for the nonmicrobicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit the Starch Utilization System and ablate the ability of Bacteroides thetaiotaomicron and B. fragilis strains to metabolize potato starch and pullulan. This strategy has potential therapeutic relevance for the selective modulation of the GI microbiota in a nonmicrobicidal manner.

PMID:
29660284
DOI:
10.1021/acschembio.8b00309

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