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Anal Chem. 2019 Apr 2;91(7):4296-4300. doi: 10.1021/acs.analchem.8b05875. Epub 2019 Mar 19.

Flexible and Superwettable Bands as a Platform toward Sweat Sampling and Sensing.

He X1, Xu T1, Gu Z1, Gao W2, Xu LP1, Pan T3,4, Zhang X1,5.

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Research Center for Bioengineering and Sensing Technology, Department of Chemistry and Biological Engineering , University of Science and Technology Beijing , Beijing 100083 , P. R. China.
Division of Engineering and Applied Science , California Institute of Technology , 1200 East California Boulevard , Pasadena , California 91125 , United States.
Department of Biomedical Engineering , University of California , Davis , California 95616 , United States.
Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , Shenzhen , Guangdong 518055 , P. R. China.
Beijing Advanced Innovation Center for Materials Genome Engineering , University of Science & Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China.


Wearable biosensors as a user-friendly measurement platform have become a rapidly growing field of interests due to their possibility in integrating traditional medical diagnostics and healthcare management into miniature lab-on-body analytic devices. This paper demonstrates a flexible and skin-mounted band that combines superhydrophobic-superhydrophilic microarrays with nanodendritic colorimetric biosensors toward in situ sweat sampling and analysis. Particularly, on the superwettable bands, the superhydrophobic background could confine microdroplets into superhydrophilic microwells. On-body investigations further reveal that the secreted sweat is repelled by the superhydrophobic silica coating and precisely collected and sampled onto the superhydrophilic micropatterns with negligible lateral spreading, which provides an independent "vessel" toward cellphone-based sweat biodetection (pH, chloride, glucose and calcium). Such wearable, superwettable band-based biosensors with improved interface controllability could significantly enhance epidemical sweat sampling in well-defined sites, holding a great promise for facile and noninvasive biofluids analysis.

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