Format

Send to

Choose Destination
ACS Med Chem Lett. 2018 Mar 8;9(4):328-333. doi: 10.1021/acsmedchemlett.7b00493. eCollection 2018 Apr 12.

New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells.

Author information

1
Departamento de Ciencias Farmacéuticas, Área de Química Farmacéutica, Facultad de Farmacia, CIETUS/IBSAL, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
2
Departamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, 37008 Salamanca, Spain.
3
Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain.
4
Proteomics Unit. Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain.

Abstract

A new family of molecular hybrids, between cyclolignans related to podophyllic aldehyde and several diterpenylnaphthohydroquinones (DNHQ), was prepared and its biological activity evaluated in several human solid tumor cell lines, which are representative of the most prevalent solid tumors in the Western world. Both cyclolignan and quinone fragments were linked through aliphatic or aromatic spacers. The new hybrid family was evaluated for its cytotoxicity, and it was found that the hybrids were several times more potent against the osteosarcoma cell line MG-63 than against MCF-7 and HT-29 cell lines. The presence of an aromatic ring in the linker gave the most potent and selective agent, improving the cytotoxicity of the parent compounds. Cell cycle studies demonstrated that this hybrid induces a strong and rapid apoptotic effect and arrests cells at the G2/M phase of the cell cycle, in the same way that the parent compound podophyllic aldehyde does.

PMID:
29670695
PMCID:
PMC5900346
[Available on 2019-04-12]
DOI:
10.1021/acsmedchemlett.7b00493

Conflict of interest statement

The authors declare no competing financial interest.

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center