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Trends Cogn Sci. 2019 Sep;23(9):717-720. doi: 10.1016/j.tics.2019.06.004. Epub 2019 Jul 11.

At the Heart of Cognitive Functioning in Aging.

Author information

1
Department of Radiation Sciences, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
2
Department of Radiation Sciences, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden. Electronic address: lars.nyberg@umu.se.

Abstract

Several neural and non-neural factors contribute to individual differences in cognitive performance. Here we outline a sequence of vascular events where excessive transfer of arterial-pressure pulsatility damages hippocampal capillaries. We argue that the vascular alterations decrease the ability to sustain neural activity and thereby contribute to episodic-memory impairment in aging.

KEYWORDS:

arteries; blood–brain barrier; brain maintenance; episodic memory; hippocampus; neurovascular coupling; vascular

PMID:
31303538
DOI:
10.1016/j.tics.2019.06.004

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