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Cell Stem Cell. 2019 Jun 6;24(6):855-859. doi: 10.1016/j.stem.2019.04.018.

Tissue-Engineering the Intestine: The Trials before the Trials.

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Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, the Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands.
STEMCELL Technologies, Vancouver, BC, Canada.
Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Institute of Chemical Sciences and Engineering, School of Basic Science, EPFL, Lausanne, Switzerland.
Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge, Cambridge, UK.
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Nine Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK.
Developmental Biology and Regenerative Medicine Program, The Saban Research Institute at Children's Hospital Los Angeles, Los Angeles, CA, USA; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck Medical School, University of Southern California, Los Angeles, CA, USA.
Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen N, Denmark; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:
Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:


Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function.


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