Format

Send to

Choose Destination
Neuroimage Clin. 2018 Dec 3. pii: S2213-1582(18)30375-9. doi: 10.1016/j.nicl.2018.101627. [Epub ahead of print]

Linked MRI signatures of the brain's acute and persistent response to concussion in female varsity rugby players.

Author information

1
Medical Biophysics, Western University, London, ON, Canada; Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada. Electronic address: kmanning@robarts.ca.
2
Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands. Electronic address: a.llera@donders.ru.nl.
3
Molecular Medicine Research Laboratories, Robarts Research Institute, London, ON, Canada; Microbiology and Immunology, Western University, London, ON, Canada. Electronic address: dekaban@robarts.ca.
4
Medical Biophysics, Western University, London, ON, Canada; Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada. Electronic address: rbartha@robarts.ca.
5
Molecular Medicine Research Laboratories, Robarts Research Institute, London, ON, Canada. Electronic address: cbarreira@robarts.ca.
6
Molecular Medicine Research Laboratories, Robarts Research Institute, London, ON, Canada; Anatomy and Cell Biology, Western University, London, ON, Canada. Electronic address: abrown@robarts.ca.
7
Primary Care Sport Medicine, Fowler Kennedy Sport Medicine, London, ON, Canada. Electronic address: lfischer@uwo.ca.
8
Primary Care Sport Medicine, Fowler Kennedy Sport Medicine, London, ON, Canada. Electronic address: tjevremo@uwo.ca.
9
Molecular Medicine Research Laboratories, Robarts Research Institute, London, ON, Canada; Microbiology and Immunology, Western University, London, ON, Canada. Electronic address: kblackne@uwo.ca.
10
Physical Medicine and Rehabilitation, Western University, London, ON, Canada. Electronic address: tim.doherty@lhsc.on.ca.
11
Paediatrics Critical Care Medicine, London Health Sciences Centre, London, ON, Canada. Electronic address: douglas.fraser@lhsc.on.ca.
12
Occupational Therapy, Western University, London, ON, Canada. Electronic address: jholme@uwo.ca.
13
Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands; Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands; Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, United Kingdom. Electronic address: c.beckmann@donders.ru.nl.
14
Medical Biophysics, Western University, London, ON, Canada; Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada. Electronic address: rmenon@robarts.ca.

Abstract

Acute brain changes are expected after concussion, yet there is growing evidence of persistent abnormalities well beyond clinical recovery and clearance to return to play. Multiparametric MRI is a powerful approach to non-invasively study structure-function relationships in the brain, however it remains challenging to interpret the complex and heterogeneous cascade of brain changes that manifest after concussion. Emerging conjunctive, data-driven analysis approaches like linked independent component analysis can integrate structural and functional imaging data to produce linked components that describe the shared inter-subject variance across images. These linked components not only offer the potential of a more comprehensive understanding of the underlying neurobiology of concussion, but can also provide reliable information at the level of an individual athlete. In this study, we analyzed resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI) within a cohort of female varsity rugby players (n = 52) through the in- and off-season, including concussed athletes (n = 21) who were studied longitudinally at three days, three months and six months after a diagnosed concussion. Linked components representing co-varying white matter microstructure and functional network connectivity characterized (a) the brain's acute response to concussion and (b) persistent alterations beyond clinical recovery. Furthermore, we demonstrate that these long-term brain changes related to specific aspects of a concussion history and allowed us to monitor individual athletes before and longitudinally after a diagnosed concussion.

KEYWORDS:

Concussion; Diffusion weighted imaging; Functional MRI; Linked independent component analysis; Mild traumatic brain injury; Resting state connectivity

PMID:
30528959
DOI:
10.1016/j.nicl.2018.101627
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center