Format

Send to

Choose Destination
Neuron. 2019 Mar 20;101(6):1150-1165.e8. doi: 10.1016/j.neuron.2019.01.009. Epub 2019 Jan 31.

Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning.

Author information

1
Department of Psychiatry, Columbia University, New York, NY 10032, USA.
2
Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
3
Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece.
4
Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece; School of Medicine, University of Crete, Heraklion, Crete 741 00, Greece.
5
Department of Neuroscience, Columbia University, New York, NY 10027, USA.
6
Center for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
7
Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece. Electronic address: poirazi@imbb.forth.gr.
8
Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY, USA. Electronic address: al2856@columbia.edu.

Abstract

Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chronic two-photon calcium imaging in mice performing random foraging or goal-oriented learning tasks, we found that vasoactive intestinal polypeptide-expressing (VIP+), disinhibitory INs in hippocampal area CA1 form functional subpopulations defined by their modulation by behavioral states and task demands. Optogenetic manipulations of VIP+ INs and computational modeling further showed that VIP+ disinhibition is necessary for goal-directed learning and related reorganization of hippocampal pyramidal cell population dynamics. Our results demonstrate that disinhibitory circuits in the hippocampus play an active role in supporting spatial learning. VIDEO ABSTRACT.

KEYWORDS:

VIP; disinhibition; hippocampus; inhibition; place cell; reward; spatial learning; two-photon

PMID:
30713030
PMCID:
PMC6428605
[Available on 2020-03-20]
DOI:
10.1016/j.neuron.2019.01.009

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center