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Mech Dev. 2017 Feb;143:9-19. doi: 10.1016/j.mod.2016.12.002. Epub 2016 Dec 19.

Mechanisms of retinoic acid signaling during cardiogenesis.

Author information

1
Aix Marseille Univ, INSERM, GMGF, Marseille, France. Electronic address: sonia.stefanovic@univ-amu.fr.
2
Aix Marseille Univ, INSERM, GMGF, Marseille, France. Electronic address: stephane.zaffran@univ-amu.fr.

Abstract

Substantial experimental and epidemiological data have highlighted the interplay between nutritional and genetic factors in the development of congenital heart defects. Retinoic acid (RA), a derivative of vitamin A, plays a key role during vertebrate development including the formation of the heart. Retinoids bind to RA and retinoid X receptors (RARs and RXRs) which then regulate tissue-specific genes. Here, we will focus on the roles of RA signaling and receptors in gene regulation during cardiogenesis, and the consequence of deregulated retinoid signaling on heart formation and congenital heart defects.

KEYWORDS:

Cell fate decisions; Heart development; Retinoic acid; Retinoic acid receptors

PMID:
28007475
DOI:
10.1016/j.mod.2016.12.002
[Indexed for MEDLINE]
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