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Alzheimers Dement. 2019 May;15(5):709-719. doi: 10.1016/j.jalz.2018.12.010. Epub 2019 Feb 10.

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).

Author information

1
Grupo de Neurociencias de Antioquia, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
2
Grupo de Neurociencias de Antioquia, School of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia; Neuroscience Research Institute, University of California, Santa Barbara, CA, USA; Department of Molecular Cellular and Developmental Biology University of California, Santa Barbara, CA, USA.
3
Department of Neurology, University of California, San Francisco, CA, USA.
4
HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
5
Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
6
Neuroscience Research Institute, University of California, Santa Barbara, CA, USA; Department of Molecular Cellular and Developmental Biology University of California, Santa Barbara, CA, USA. Electronic address: Kenneth.kosik@lifesci.ucsb.edu.

Abstract

INTRODUCTION:

A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a family with a novel variant in PSEN1.

METHODS:

We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing.

RESULTS:

Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 years (standard deviation 5.03).

DISCUSSION:

Ile416Thr is a novel pathogenic variant that causes AD in the sixth decade of life. The history of the region that included slave importation and admixtures within a confined geographic locale represents a "mini-population bottleneck" and subsequent emergence of a rare dominant mutation.

KEYWORDS:

Admixture in Latin America; Autosomal dominant Alzheimer's disease; Founder effect; Genetic Bottleneck; Genetic drift; Phenotype genotype correlation; Presenilin 1

PMID:
30745123
PMCID:
PMC6511480
[Available on 2020-05-01]
DOI:
10.1016/j.jalz.2018.12.010

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