Format

Send to

Choose Destination
Curr Biol. 2019 May 6;29(9):1436-1444.e5. doi: 10.1016/j.cub.2019.03.048. Epub 2019 Apr 25.

Post-learning Hippocampal Replay Selectively Reinforces Spatial Memory for Highly Rewarded Locations.

Author information

1
NERF, Kapeldreef 75, 3001 Leuven, Belgium; Brain & Cognition, KU Leuven, Tiensestraat 102, 3000 Leuven, Belgium; VIB, Rijvisschestraat 120, 9052 Ghent, Belgium.
2
NERF, Kapeldreef 75, 3001 Leuven, Belgium; imec, Remisebosweg 1, 3001 Leuven, Belgium.
3
NERF, Kapeldreef 75, 3001 Leuven, Belgium; Department of Physiology, College of Medicine, Seoul National University, 28 Yeongeon-dong, 03080 Jongno-gu, Seoul, South Korea.
4
NERF, Kapeldreef 75, 3001 Leuven, Belgium; Brain & Cognition, KU Leuven, Tiensestraat 102, 3000 Leuven, Belgium; VIB, Rijvisschestraat 120, 9052 Ghent, Belgium; imec, Remisebosweg 1, 3001 Leuven, Belgium. Electronic address: fabian.kloosterman@nerf.be.

Abstract

Offline replay of hippocampal neural patterns supports the acquisition of new tasks in novel contexts, but its contribution to consolidation of salient experiences in a familiar context is unknown. Here, we show that in a highly familiar spatial memory task, large rewards selectively enhanced performance for demanding task configurations. The reward-related enhancement was sensitive to ripple-specific disruption, and the proportion of replay events positively correlated with reward size and task demands. Hippocampal replay thus selectively enhances memory of highly rewarded locations in a familiar context.

KEYWORDS:

behavior; consolidation; hippocampus; memory; rats; replay; reward; sharp wave ripples

PMID:
31031113
DOI:
10.1016/j.cub.2019.03.048

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center