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Curr Biol. 2018 Sep 24;28(18):2948-2954.e3. doi: 10.1016/j.cub.2018.06.070. Epub 2018 Sep 13.

Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.

Author information

1
School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
2
School of Medicine, University of California, San Francisco, CA, USA.
3
School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA, USA. Electronic address: pathunt@wsu.edu.

Abstract

20 years ago, accidental bisphenol A (BPA) exposure caused a sudden increase in chromosomally abnormal eggs from our control mice [1]. Subsequent rodent studies demonstrated developmental effects of exposure with repercussions on adult health and fertility (e.g., [2-9]; reviewed in [10-17]). Studies in monkeys, humans, fish, and worms suggest BPA effects extend across species (e.g., [18-30]; reviewed in [31-33]). Widespread use has resulted in ubiquitous environmental contamination and human BPA exposure. Consumer concern resulted in "BPA-free" products produced using structurally similar bisphenols that are now detectable environmental and human contaminants (e.g., [34-41]). We report here studies initiated by meiotic changes mirroring our previous BPA experience and implicating exposure to BPS (a common BPA replacement) from damaged polysulfone cages. Like with BPA [1, 2, 5], our data show that exposure to common replacement bisphenols induces germline effects in both sexes that may affect multiple generations. These findings add to growing evidence of the biological risks posed by this class of chemicals. Rapid production of structural variants of BPA and other EDCs circumvents efforts to eliminate dangerous chemicals, exacerbates the regulatory burden of safety assessment, and increases environmental contamination. Our experience suggests that these environmental contaminants pose a risk not only to reproductive health but also to the integrity of the research environment. EDCs, like endogenous hormones, can affect diverse processes. The sensitivity of the germline allows us to detect effects that, although not immediately apparent in other systems, may induce variability that undermines experimental reproducibility and impedes scientific advancement.

KEYWORDS:

BPA; BPS; EDCs; bisphenols; meiosis; oogenesis; spermatogenesis; transgenerational

PMID:
30220498
PMCID:
PMC6156992
[Available on 2019-09-24]
DOI:
10.1016/j.cub.2018.06.070

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