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Cell Metab. 2019 May 16. pii: S1550-4131(19)30248-7. doi: 10.1016/j.cmet.2019.05.008. [Epub ahead of print]

Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.

Author information

1
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. Electronic address: kevinh@nih.gov.
2
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
3
National Institutes of Health Clinical Center, Bethesda, MD, USA.
4
Singapore Institute for Clinical Sciences, Singapore, Singapore.
5
National Institute of Nursing Research, Bethesda, MD, USA.

Abstract

We investigated whether ultra-processed foods affect energy intake in 20 weight-stable adults, aged (mean ± SE) 31.2 ± 1.6 years and BMI = 27 ± 1.5 kg/m2. Subjects were admitted to the NIH Clinical Center and randomized to receive either ultra-processed or unprocessed diets for 2 weeks immediately followed by the alternate diet for 2 weeks. Meals were designed to be matched for presented calories, energy density, macronutrients, sugar, sodium, and fiber. Subjects were instructed to consume as much or as little as desired. Energy intake was greater during the ultra-processed diet (508 ± 106 kcal/day; p = 0.0001), with increased consumption of carbohydrate (280 ± 54 kcal/day; p < 0.0001) and fat (230 ± 53 kcal/day; p = 0.0004), but not protein (-2 ± 12 kcal/day; p = 0.85). Weight changes were highly correlated with energy intake (r = 0.8, p < 0.0001), with participants gaining 0.9 ± 0.3 kg (p = 0.009) during the ultra-processed diet and losing 0.9 ± 0.3 kg (p = 0.007) during the unprocessed diet. Limiting consumption of ultra-processed foods may be an effective strategy for obesity prevention and treatment.

KEYWORDS:

diet quality; energy balance; energy intake; processed food; weight gain; weight loss

PMID:
31105044
DOI:
10.1016/j.cmet.2019.05.008

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