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Cell Metab. 2018 Dec 18. pii: S1550-4131(18)30744-7. doi: 10.1016/j.cmet.2018.12.007. [Epub ahead of print]

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial.

Author information

1
The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
2
Department of Radiology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
3
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen, Denmark; Department of Rheumatology, Odense University Hospital, 5000 Odense, Denmark.
4
Department of Cardiology, Copenhagen University Hospital Bispebjerg, Copenhagen, 2400 Copenhagen, Denmark.
5
The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: helga.ellingsgaard@regionh.dk.

Abstract

Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

PMID:
30595477
DOI:
10.1016/j.cmet.2018.12.007

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