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Cell. 2019 Mar 21;177(1):85-100. doi: 10.1016/j.cell.2019.01.033.

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Author information

1
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada. Electronic address: michael.costanzo@utoronto.ca.
2
Goodman Cancer Research Centre, McGill University, Montreal QC, Canada.
3
Center for Integrative Genomics, Université de Lausanne, Switzerland.
4
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada.
5
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada.
6
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada. Electronic address: charlie.boone@utoronto.ca.
7
The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada. Electronic address: brenda.andrews@utoronto.ca.

Abstract

Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation of allelic combinations of genes underlying inherited traits. In this Review, we discuss how large-scale analyses in model systems have illuminated the general principles and phenotypic impact of genetic interactions. We focus on studies in budding yeast, including the mapping of a global genetic network. We emphasize how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.

PMID:
30901552
DOI:
10.1016/j.cell.2019.01.033

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